ABSTRACT
With the onset of the COVID-19 pandemic, a number of public policy measures have been developed to curb the spread of the virus. However, little is known about the attitudes towards stay-at-home orders expressed on social media despite the fact that social media are central platforms for expressing and debating personal attitudes. To address this gap, we analyze the prevalence and framing of attitudes towards stay-at-home policies, as expressed on Twitter in the early months of the pandemic. We focus on three aspects of tweets: whether they contain an attitude towards stay-at-home measures, whether the attitude was for or against, and the moral justification for the attitude, if any. We collect and annotate a dataset of stay-at-home tweets and create classifiers that enable large-scale analysis of the relationship between moral frames and stay-at-home attitudes and their temporal evolution. Our findings suggest that frames of care are correlated with a supportive stance, whereas freedom and oppression signify an attitude against stay-at-home directives. There was widespread support for stay-at-home orders in the early weeks of lockdowns, followed by increased resistance toward the end of May and the beginning of June 2020. The resistance was associated with moral judgment that mapped to political divisions. © 2022 IEEE.
ABSTRACT
The SARS-CoV-2 hyperinflammatory response is associated with high mortality. This hypothesis suggests that a deficiency of nicotinamide adenine dinucleotide (NAD+) may be the primary factor related to the SARS-Cov-2 disease spectrum and the risk for mortality, as subclinical nutritional deficiencies may be unmasked by any significant increase in oxidative stress. NAD+ levels decline with age and are also reduced in conditions associated with oxidative stress as occurs with hypertension, diabetes and obesity. These groups have also been observed to have high mortality following infection with COVID-19. Further consumption of NAD+ in a pre-existent depleted state is more likely to cause progression to the hyperinflammatory stage of the disease through its limiting effects on the production of SIRT1. This provides a unifying hypothesis as to why these groups are at high risk of mortality and suggests that nutritional support with NAD+ and SIRT1 activators, could minimise disease severity if administered prophylactically and or therapeutically. The significance of this, if proven, has far-reaching consequences in the management of COVID-19 especially in third world countries, where resources and finances are limited.